p27(Kip1) expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

Mattia Barbareschi, Harm Van Tinteren, Francesco A. Mauri, Silvio Veronese, Hans Peterse, Patrik Maisonneuve, Orazio Caffo, Monica Scaioli, Claudio Doglioni, Enzo Galligioni, Paolo Dalla Palma, Rob Michalides

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61 Citaten (Scopus)


p27(Kip1) (p27), a cyclin-dependent kinase inhibitor, has an important role in the progression of cells from G1 into S phase of the cell cycle. p27 may act as a tumor suppressor, and several reports suggest that loss of its expression in breast carcinoma is related to tumor progression and poor prognosis. We evaluated p27 immunohistochemical expression in 512 consecutive cases of breast carcinoma with 9 years of median-term follow-up. p27 expression was heterogeneous and frequently less intense than in normal cells. Low p27 expression (<50% of reacting cells) was associated with grade III tumors, N0 status, estrogen receptor-negative status, and low cyclin D1 expression. In the whole series of cases, p27 expression did not predict outcome. In node-negative cases (249 patients), high p27 expression indicated poor prognosis, p27 was not prognostically relevant in the group of 223 patients with pT1 disease or in the group of 154 patients <50 years of age. We also investigated the prognostic value of the combined expression of p27 and cyclin D1, but no differences in survival were seen in this bivariate analysis. (C) 2000 Wiley-Liss, Inc.

Originele taal-2Engels
Pagina's (van-tot)236-241
Aantal pagina's6
TijdschriftInternational Journal of Cancer
Nummer van het tijdschrift3
StatusGepubliceerd - 2000
Extern gepubliceerdJa


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