P44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair

Sandrine Humbert, Hanneke Van Vuuren, Yves Lutz, Jan H.J. Hoeijmakers, Jean Marc Egly, Vincent Moncollin

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

103 Citaten (Scopus)

Samenvatting

The human BTF2 (TFIIH) transcription factor is a multisubunit protein involved in transcription initiation by RNA polymerase II (B) as well as in DNA repair. In addition to the previously characterized p62 and p89/ERCC3 subunits, we have cloned two other subunits of BTF2, p44 and p34. The gene encoding p44 appeared to be the human counterpart of SSL1, a gene involved in translation and W resistance in yeast. Interestingly, the p34 subunit also has homology with a domain of SSL1, suggesting that it corresponds to an as yet unidentified protein involved in DNA repair. Both p44 and p34 possess zinc finger domains that may mediate BTF2 binding to nucleic acids.

Originele taal-2Engels
Pagina's (van-tot)2393-2398
Aantal pagina's6
TijdschriftEMBO Journal
Volume13
Nummer van het tijdschrift10
DOI's
StatusGepubliceerd - 1994
Extern gepubliceerdJa

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