Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

Heleen D. Jüngen; Talya L. Dayton

doi:10.1016/j.devcel.2026.05.006

Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

Heleen D. Jüngen
, Talya L. Dayton

Onderzoeksoutput: Bijdrage aan tijdschrift › Opmerking/debat

Samenvatting

Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. ¹ establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

Originele taal-2	Engels
Pagina's (van-tot)	1165-1166
Aantal pagina's	2
Tijdschrift	Developmental Cell
Volume	61
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.devcel.2026.05.006
Status	Gepubliceerd - 10 jun 2026
Extern gepubliceerd	Ja

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10.1016/j.devcel.2026.05.006

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title = "Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis",

abstract = "Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.",

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note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Inc.",

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doi = "10.1016/j.devcel.2026.05.006",

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T1 - Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

AU - Jüngen, Heleen D.

AU - Dayton, Talya L.

PY - 2026/6/10

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N2 - Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

AB - Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

UR - https://www.scopus.com/pages/publications/105040907329

U2 - 10.1016/j.devcel.2026.05.006

DO - 10.1016/j.devcel.2026.05.006

M3 - Comment/debate

AN - SCOPUS:105040907329

SN - 1534-5807

VL - 61

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EP - 1166

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

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