Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

J Wolter Oosterhuis, Suzanne H P Peeters, Vincent T H B M Smit, Hans Stoop, Leendert H J Looijenga, Henk W Elzevier, Suzanne Osanto

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.

Originele taal-2Engels
Pagina's (van-tot)153-7
Aantal pagina's5
TijdschriftThe International journal of developmental biology
Volume57
Nummer van het tijdschrift2-4
DOI's
StatusGepubliceerd - 2013
Extern gepubliceerdJa

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