PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Laure Hirsch; Laurence Zitvogel; Alexander Eggermont; Aurelien Marabelle

doi:10.1038/s41416-018-0294-4

PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Laure Hirsch
, Laurence Zitvogel
, Alexander Eggermont
, Aurelien Marabelle

Onderzoeksoutput: Bijdrage aan tijdschrift › Editoriaal

104 Citaten (Scopus)

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Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers (‘PD-Lomas’) is driving the clinical research strategies for the next generation of combination immunotherapy.

Originele taal-2	Engels
Pagina's (van-tot)	3-5
Aantal pagina's	3
Tijdschrift	British journal of cancer
Volume	120
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/s41416-018-0294-4
Status	Gepubliceerd - 8 jan. 2019
Extern gepubliceerd	Ja

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10.1038/s41416-018-0294-4

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title = "PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade",

abstract = "Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers ({\textquoteleft}PD-Lomas{\textquoteright}) is driving the clinical research strategies for the next generation of combination immunotherapy.",

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AU - Marabelle, Aurelien

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AB - Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers (‘PD-Lomas’) is driving the clinical research strategies for the next generation of combination immunotherapy.

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PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

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