Pharmacokinetics and Associated Efficacy of Emicizumab in Humans: A Systematic Review

Anouk A.M.T. Donners, Carin M.A. Rademaker, Lisanne A.H. Bevers, Alwin D.R. Huitema, Roger E.G. Schutgens, Toine C.G. Egberts, Kathelijn Fischer

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

19 Citaten (Scopus)


Introduction: Emicizumab is an effective new treatment option for people with hemophilia A (PwHA). The approved dosing regimens are based on body weight, without the necessity for laboratory monitoring. This assumes a clear dose–concentration–response relationship, with acceptable variability due to factors other than body weight. To investigate this assumption, a systematic review on the pharmacokinetics (PK) and associated efficacy of emicizumab in humans was conducted. Methods: The EMBASE, Pubmed and CENTRAL databases were systematically searched to November 2020 to identify studies on the PK data of emicizumab in humans. Data on the study, population, PK and efficacy (annualized bleeding rate of treated [joint] bleeds) were extracted and synthesized, and exposure effects modeling was performed using non-linear least squares regression in a maximum effect (Emax) model. Results: The 15 included studies reported on data for 140 volunteers and 467 PwHA, including children (0 to <12 years) and adolescents and adults (≥12 years), both with and without factor VIII (FVIII) inhibitors. Emicizumab demonstrated dose-linear PK. The interindividual variability of trough concentrations was moderate (32%) and was similar across various subgroups, such as FVIII inhibitor status, age group and dosing interval. The control of bleeds did not further improve above emicizumab concentrations of 30 µg/mL, potentially enabling lower dosing in a substantial proportion of PwHA. Conclusion: This review supports body weight-based dosing, although individualized monitoring of emicizumab concentrations may allow for more cost-effective dosing.

Originele taal-2Engels
Pagina's (van-tot)1395-1406
Aantal pagina's12
TijdschriftClinical Pharmacokinetics
Nummer van het tijdschrift11
StatusGepubliceerd - nov. 2021


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