Pharmacokinetics and population pharmacokinetics in pediatric oncology

Sebastiaan D.T. Sassen, C. Michel Zwaan, Inge M. van der Sluis, Ron A.A. Mathôt

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

7 Citaten (Scopus)


Pharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of heterogeneous data, and identification of variability sources. However, population pharmacokinetic reports can be complex and difficult to interpret. The aim of this article is to provide a basic explanation of population pharmacokinetics, using clinical examples from the field of pediatric oncology, to facilitate the translation of pharmacokinetic research into the daily clinic.

Originele taal-2Engels
TijdschriftPediatric Blood and Cancer
Nummer van het tijdschrift4
StatusGepubliceerd - 1 apr. 2020


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