Placing the Plasmodium falciparum epigenome on the map

Wieteke A.M. Hoeijmakers, Hendrik G. Stunnenberg, Richárd Bártfai

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

27 Citaten (Scopus)


It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmodium falciparum started to flourish in recent years due to improvement of genomic technologies. Here we summarize the knowledge gained from genome-wide localization profiling of different epigenetic features, and discuss hypotheses emerging from the analysis of these 'descriptive' epigenetic maps. Furthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level.

Originele taal-2Engels
Pagina's (van-tot)486-495
Aantal pagina's10
TijdschriftTrends in Parasitology
Nummer van het tijdschrift11
StatusGepubliceerd - nov. 2012
Extern gepubliceerdJa


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