@article{ecab1f77df7646b788c033a6e9cb4c91,
title = "Placing the Plasmodium falciparum epigenome on the map",
abstract = "It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmodium falciparum started to flourish in recent years due to improvement of genomic technologies. Here we summarize the knowledge gained from genome-wide localization profiling of different epigenetic features, and discuss hypotheses emerging from the analysis of these 'descriptive' epigenetic maps. Furthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level.",
keywords = "Chromatin, Epigenome, Histone modification, Histone variant, Malaria, Nucleosome, Plasmodium",
author = "Hoeijmakers, {Wieteke A.M.} and Stunnenberg, {Hendrik G.} and Rich{\'a}rd B{\'a}rtfai",
note = "Funding Information: We would like to thank our colleagues at the Departments of Molecular Biology and Medical Microbiology for valuable discussions and ideas, our collaborators for excellent collaboration on various projects, and specifically Dr Adriana Salcedo-Amaya for pioneering the wonderful world of Plasmodium epigenetics in our lab. Furthermore, we would like to thank the organizers of MAM 2012 for an excellent and stimulating meeting and the PlasmoDB team for providing an invaluable resource on genome-wide data in Plasmodium. We would like to acknowledge M. Petter, S. Selvarajah, and M. Duffy for sharing with us their unpublished data on PfH2B.Z localization to the active var promoter. We are grateful to the Netherlands Organization for Scientific Research (ZonMw/NGI Horizon 93511023 to R.B., NWO-TopTalent 021.001.011 to W.A.M.H.), the European Commission (EVIMalaR EU-FP7_242095 to H.G.S., OzEMalaR EU-FP7 to W.A.M.H.) and the United States Government National Institute of Allergy and Infectious Diseases (EuPathDB BRC Driving Biological Projects 2012 to H.G.S. and R.B.) for funding. We apologize to those colleagues whose work could not be cited due to citation number limitations and date restrictions.",
year = "2012",
month = nov,
doi = "10.1016/j.pt.2012.08.006",
language = "English",
volume = "28",
pages = "486--495",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Ltd.",
number = "11",
}