Poised RNA Polymerase II Gives Pause for Thought

Thanasis Margaritis; Frank C.P. Holstege

doi:10.1016/j.cell.2008.04.027

Poised RNA Polymerase II Gives Pause for Thought

Thanasis Margaritis
, Frank C.P. Holstege

Onderzoeksoutput: Bijdrage aan tijdschrift › Kort overzicht › peer review

128 Citaten (Scopus)

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Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

Originele taal-2	Engels
Pagina's (van-tot)	581-584
Aantal pagina's	4
Tijdschrift	Cell
Volume	133
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.cell.2008.04.027
Status	Gepubliceerd - 16 mei 2008
Extern gepubliceerd	Ja

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title = "Poised RNA Polymerase II Gives Pause for Thought",

abstract = "Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.",

author = "Thanasis Margaritis and Holstege, \{Frank C.P.\}",

note = "Funding Information: We thank E. Birney, M. Timmers, and R. Medema for helpful comments. F.H. is supported by the Netherlands Organization for Scientific Research grants 80547080, 91106009, 05071057, and 81702015 and the Netherlands Bioinformatics Centre.",

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N2 - Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

AB - Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

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Poised RNA Polymerase II Gives Pause for Thought

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