Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia

A Hartman, R H N van Schaik, I P van der Heiden, M J C Broekhuis, M Meier, M L den Boer, R Pieters

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

INTRODUCTION: Impaired motor performance in children who completed treatment for acute lymphoblastic leukemia (ALL) may be related to polymorphisms of the metabolising gene CYP3A5 or vincristine toxicity related genes MDR-1 and MAPT.

METHODS: Motor performance was measured with the Movement Assessment Battery for Children (movement-ABC). DNA, from mononuclear blood cells was genotyped for CYP3A5, MDR-1 and MAPT polymorphisms.

RESULTS: Motor performance was not significantly affected by CYP3A5*3/*3 and CYP3A5*1*3 genotypes, MDR-1 polymorphisms or MAPT haplotype.

CONCLUSION: Our data did not show that CYP3A5, MDR-1 or MAPT polymorphisms are linked to impaired motor performance in children after treatment for ALL.

Originele taal-2Engels
Pagina's (van-tot)154-9
Aantal pagina's6
TijdschriftLeukemia research
Volume34
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - feb. 2010
Extern gepubliceerdJa

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