Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Keyphrases

• Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) 100%
• Population Pharmacokinetics 100%
• Fludarabine 100%
• Hematopoietic Cell Transplantation 100%
• Estimated Glomerular Filtration Rate 60%
• Pharmacokinetics 40%
• Body Surface Area 40%
• Area-based 40%
• Volume of Distribution 20%
• Body Size 20%
• Area under the Curve 20%
• Nonlinear Mixed Effects 20%
• Population Pharmacokinetic Model 20%
• Treatment Outcome 20%
• Allometric Scaling 20%
• All Ages 20%
• Pharmacokinetic Parameters 20%
• Time of Concentration 20%
• Renal Function 20%
• Weight Range 20%
• Time-varying Data 20%
• First-order Kinetics 20%
• Size Descriptor 20%
• Actual Weight 20%
• Three-compartment Model 20%
• Circulating Metabolites 20%
• Reduced-toxicity Conditioning Regimen 20%
• Result Variability 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Fludarabine 100%
• Pharmacokinetics 100%
• Volume of Distribution 20%
• Pharmacokinetic Parameter 20%