Präoperative strahlentherapie verbessert das ergebnis bei rezidiven eines rektumkarzinoms

Maarten Vermaas, Floris T.J. Ferenschild, Joost J.M.E. Nuyttens, Andreas W.K.S. Marinelli, Theo Wiggers, Joost R.M.M. Van Der Sijp, Cornelis Verhoef, Wilfried J. Graveland, Alexander M.M. Eggermont, Johannes H.W. De Wilt

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

1 Citaat (Scopus)


Purpose: When local recurrent rectal cancer is diagnosed without signs of metastases, a potentially curative resection can be performed. This study was designed to compare the results of preoperative radiotherapy followed by surgery with surgery only. Methods: Between 1985 and 2003, 117 patients with recurrent rectal cancer were prospectively entered in our database. Ninety-two patients were suitable for resection with curative intent. Preoperative radiation with a median dosage of 50 Gy was performed in 59 patients; 33 patients did not receive preoperative radiotherapy. The median age of the patients was 66 and 62 years, respectively. Results: The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64% of the patients who received preoperative radiation and 45% of the nonirradiated patients. A complete response after radiotherapy was found in 10% of the preoperatively irradiated patients (n = 6). There were no differences in morbidity and reintervention rate between the two groups. Local control after preoperative radiotherapy was statistically significantly higher after three and five years (p = 0,036). Overall survival and metastases-free survival were not different in both groups. Complete response to preoperative radiotherapy was predictive for an improved survival. Conclusions: Preoperative radiotherapy for recurrent rectal cancer results in a higher number of complete resections and an improved local control compared with patients treated without radiotherapy. Preoperative radiotherapy should be standard treatment for patients with recurrent rectal cancer.

Vertaalde titel van de bijdragePreoperative radiotherapy improves outcome in recurrent rectal cancer
Originele taal-2Duits
Pagina's (van-tot)85-96
Aantal pagina's12
Nummer van het tijdschrift2
StatusGepubliceerd - apr. 2006
Extern gepubliceerdJa


  • Cancer
  • Preoperative radiotherapy
  • Rectal
  • Recurrence


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