Prevalence of human respiratory syncytial virus circulating in Iran

Vahid Salimi, Masoumeh Tavakoli-Yaraki, Jila Yavarian, Louis Bont, Talat Mokhtari-Azad

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

35 Citaten (Scopus)


Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection during early childhood and is associated with a great burden on patients, parents, and society. While no treatment is yet available, results from recent phase 2 clinical trials of cell-entry inhibitors and RSV vaccines are promising. To prepare for introduction of these novel therapeutics, good understanding of its molecular epidemiology and continuous RSV surveillance data are necessary. This paper provides an overview of RSV prevalence and genotype distribution in Iran from 1996 to 2013. This meta-analysis includes 21 published studies. In total, 775 (18.7%) of 4140 respiratory specimens were positive for RSV infection. The male-female ratio of RSV-positive patients was 1.5:1. Significant peaks of RSV infection were detected during the cold season (November-March). RSV infection was mainly observed in patients <2 years of age. Phylogenetic studies showed that genotypes GA1, GA2, GA5, and BA co-circulated in Iran in 2007-2013. This review highlights the necessity of introducing standard molecular surveillance programs to inform the epidemiological, clinical, and pathological characteristics of various RSV genotypes. Improved understanding of the molecular epidemiology will be useful for development of novel RSV therapeutics.

Originele taal-2Engels
Pagina's (van-tot)125-135
Aantal pagina's11
TijdschriftJournal of Infection and Public Health
Nummer van het tijdschrift2
StatusGepubliceerd - 1 mrt. 2016
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Prevalence of human respiratory syncytial virus circulating in Iran'. Samen vormen ze een unieke vingerafdruk.

Citeer dit