Prognostic significance of 99mTc Hynic-rh-annexin V scintigraphy during platinum-based chemotherapy in advanced lung cancer

Marina Kartachova, Nico Van Zandwijk, Sjaak Burgers, Harm Van Tinteren, Marcel Verheij, Renato Alfredo Valdés Olmos

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

86 Citaten (Scopus)

Samenvatting

Purpose: The purpose of this study was to evaluate if sequential 99mTmTc Hynic-rh- annexin V scintigraphy (TAS) can predict outcome in patients with advanced lung cancer, shortly after the start of platinum-based chemotherapy. Patients and Methods: In 16 consecutive chemotherapy-naive patients with advanced stage non-small-cell lung cancer scheduled for platinum-based chemotherapy, TAS was performed before and within 48 hours after the start of therapy. Chemotherapy-induced changes in tumor annexin V uptake, calculated as maximum count per pixel and expressed as percentage to baseline value, were compared with treatment response determined according to Response Evaluation Criteria in Solid Tumors. Results: A significant correlation (r 2 = 0.86; P = .0001) was found between annexin V metabolic changes and treatment outcome. All patients with notably increased annexin V tumor uptake showed complete or partial response. Less prominently increased or decreased uptake correlated with stable or progressive disease. Conclusion: TAS is a promising test to predict tumor response in patients with advanced lung cancer early in the course of platinum-based chemotherapy.

Originele taal-2Engels
Pagina's (van-tot)2534-2539
Aantal pagina's6
TijdschriftJournal of Clinical Oncology
Volume25
Nummer van het tijdschrift18
DOI's
StatusGepubliceerd - 20 jun. 2007
Extern gepubliceerdJa

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