Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

S. A.G. Kemink, P. Wesseling, G. F.F.M. Pieters, A. A.J. Verhofstad, A. R.M.M. Hermus, A. G.H. Smals

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

37 Citaten (Scopus)

Samenvatting

A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

Originele taal-2Engels
Pagina's (van-tot)70-75
Aantal pagina's6
TijdschriftJournal of Endocrinological Investigation
Volume22
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 1999
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature'. Samen vormen ze een unieke vingerafdruk.

Citeer dit