Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

S. A.G. Kemink; P. Wesseling; G. F.F.M. Pieters; A. A.J. Verhofstad; A. R.M.M. Hermus; A. G.H. Smals

doi:10.1007/BF03345482

Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

S. A.G. Kemink, P. Wesseling, G. F.F.M. Pieters, A. A.J. Verhofstad, A. R.M.M. Hermus, A. G.H. Smals

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

8 Citaten (Scopus)

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A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

Originele taal-2	Engels
Pagina's (van-tot)	70-75
Aantal pagina's	6
Tijdschrift	Journal of Endocrinological Investigation
Volume	22
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1007/BF03345482
Status	Gepubliceerd - 1999
Extern gepubliceerd	Ja

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title = "Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature",

abstract = "A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.",

keywords = "Carcinoma, Cushing, Histology, Metastasis, Pituitary",

author = "Kemink, {S. A.G.} and P. Wesseling and Pieters, {G. F.F.M.} and Verhofstad, {A. A.J.} and Hermus, {A. R.M.M.} and Smals, {A. G.H.}",

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T1 - Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

AU - Kemink, S. A.G.

AU - Wesseling, P.

AU - Pieters, G. F.F.M.

AU - Verhofstad, A. A.J.

AU - Hermus, A. R.M.M.

AU - Smals, A. G.H.

PY - 1999

Y1 - 1999

N2 - A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

AB - A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

KW - Carcinoma

KW - Cushing

KW - Histology

KW - Metastasis

KW - Pituitary

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JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

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Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

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