Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

Antoinette D. Reichert, Marloes Nies, Wim J.E. Tissing, Anneke C. Muller Kobold, Mariëlle S. Klein Hesselink, Adrienne H. Brouwers, Bas Havekes, Marry M. van den Heuvel-Eibrink, Helena J.H. van der Pal, John T.M. Plukker, Hanneke M. van Santen, Eleonora P.M. Corssmit, Romana T. Netea-Maier, Robin P. Peeters, Eveline W.C.M. van Dam, Johannes G.M. Burgerhof, Peter van der Meer, Gianni Bocca, Thera P. Links

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review


Background: Pediatric differentiated thyroid cancer (DTC) has an excellent prognosis but unknown late effects of treatment. The initial cardiac evaluation showed subclinical diastolic dysfunction in 20% of adult survivors. The objective of this follow-up study was to determine the clinical course of this finding. Methods: This multicenter study, conducted between 2018 and 2020, re-evaluated survivors after 5 years. The primary endpoint was echocardiographic diastolic cardiac function (depicted by the mean of the early diastolic septal and early diastolic lateral tissue velocity (e’ mean)). Secondary endpoints were other echocardiographic parameters and plasma biomarkers. Results: Follow-up evaluation was completed in 47 (71.2%) of 66 survivors who had completed their initial evaluation. Of these 47 survivors, 87.2% were women. The median age was 39.8 years (range: 18.8–60.3), and the median follow-up after the initial diagnosis was 23.4 years (range: 10.2–48.8). Between the first and second evaluation, the e’ mean significantly decreased by 2.1 cm/s (s.d. 2.3 cm/s, P < 0.001). The median left ventricular ejection fraction did not significantly change (58.0% vs 59.0%, P= NS). In the best explanatory model of e’ mean, multivariate linear regression analysis showed that BMI and age were significantly associated with e’ mean (β coefficient: -0.169, 95% CI: -0.292; -0.047, P = 0.008 and β coefficient: -0.177, 95% CI: -0.240; -0.113, P < 0.001, respectively). Conclusions and relevance: In these relatively young survivors of pediatric DTC, diastolic function decreased significantly during 5-year follow-up and is possibly more pronounced than in normal aging. This finding requires further follow-up to assess clinical consequences.

Originele taal-2Engels
Pagina's (van-tot)497-505
Aantal pagina's9
TijdschriftEuropean Journal of Endocrinology
Nummer van het tijdschrift4
StatusGepubliceerd - okt. 2022


Duik in de onderzoeksthema's van 'Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma'. Samen vormen ze een unieke vingerafdruk.

Citeer dit