Prohormone transport through the secretory pathway of neuroendocrine cells

R P Kuiper, G J Martens

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

12 Citaten (Scopus)


En route through the secretory pathway of neuroendocrine cells, prohormones pass a series of membrane-bounded compartments. During this transport, the prohormones are sorted to secretory granules and proteolytically cleaved to bioactive peptides. Recently, progress has been made in a number of aspects concerning secretory protein transport and sorting, particularly with respect to transport events in the early regions of the secretory pathway. In this review we will deal with some of these aspects, including: i) selective exit from the endoplasmic reticulum via COPII-coated vesicles and the potential role of p24 putative cargo receptors in this process, ii) cisternal maturation as an alternative model for protein transport through the Golgi complex, and iii) the mechanisms that may be involved in the sorting of regulated secretory proteins to secretory granules. Although much remains to be learned, interesting new insights into the functioning of the secretory pathway have been obtained.

Originele taal-2Engels
Pagina's (van-tot)289-98
Aantal pagina's10
TijdschriftBiochemistry and cell biology = Biochimie et biologie cellulaire
Nummer van het tijdschrift3
StatusGepubliceerd - 2000
Extern gepubliceerdJa


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