TY - JOUR
T1 - Prohormone transport through the secretory pathway of neuroendocrine cells
AU - Kuiper, R P
AU - Martens, G J
PY - 2000
Y1 - 2000
N2 - En route through the secretory pathway of neuroendocrine cells, prohormones pass a series of membrane-bounded compartments. During this transport, the prohormones are sorted to secretory granules and proteolytically cleaved to bioactive peptides. Recently, progress has been made in a number of aspects concerning secretory protein transport and sorting, particularly with respect to transport events in the early regions of the secretory pathway. In this review we will deal with some of these aspects, including: i) selective exit from the endoplasmic reticulum via COPII-coated vesicles and the potential role of p24 putative cargo receptors in this process, ii) cisternal maturation as an alternative model for protein transport through the Golgi complex, and iii) the mechanisms that may be involved in the sorting of regulated secretory proteins to secretory granules. Although much remains to be learned, interesting new insights into the functioning of the secretory pathway have been obtained.
AB - En route through the secretory pathway of neuroendocrine cells, prohormones pass a series of membrane-bounded compartments. During this transport, the prohormones are sorted to secretory granules and proteolytically cleaved to bioactive peptides. Recently, progress has been made in a number of aspects concerning secretory protein transport and sorting, particularly with respect to transport events in the early regions of the secretory pathway. In this review we will deal with some of these aspects, including: i) selective exit from the endoplasmic reticulum via COPII-coated vesicles and the potential role of p24 putative cargo receptors in this process, ii) cisternal maturation as an alternative model for protein transport through the Golgi complex, and iii) the mechanisms that may be involved in the sorting of regulated secretory proteins to secretory granules. Although much remains to be learned, interesting new insights into the functioning of the secretory pathway have been obtained.
KW - Animals
KW - Biological Transport
KW - Carrier Proteins/metabolism
KW - Endoplasmic Reticulum/metabolism
KW - Hormones/metabolism
KW - Models, Biological
KW - Neurosecretory Systems/metabolism
KW - Phosphoproteins/metabolism
KW - Phylogeny
KW - Pro-Opiomelanocortin/metabolism
KW - Protein Transport
KW - Saccharomyces cerevisiae Proteins
KW - Vesicular Transport Proteins
KW - Xenopus
KW - trans-Golgi Network/metabolism
M3 - Review article
C2 - 10949080
SN - 0829-8211
VL - 78
SP - 289
EP - 298
JO - Biochemistry and cell biology = Biochimie et biologie cellulaire
JF - Biochemistry and cell biology = Biochimie et biologie cellulaire
IS - 3
ER -