PROTAC-Mediated GSPT1 Degradation Impairs the Expression of Fusion Genes in Acute Myeloid Leukemia

Keyphrases

• Fusion Gene 100%
• Acute Myeloid Leukemia 100%
• Proteolysis Targeting chimera (PROTAC) 100%
• GSPT1 100%
• Pediatric Leukemia 42%
• Leukemia 28%
• Acute Myeloid Leukemia Cells 28%
• RUNX1-RUNX1T1 28%
• ERG Fusion 28%
• FUS-ERG 28%
• Tumor Growth 14%
• New Therapeutic Approaches 14%
• Hematological Malignancies 14%
• Transcription Factor 14%
• Clinical Development 14%
• Cell Cycle Arrest 14%
• Apoptosis 14%
• Runt-related Transcription Factor 1 (RUNX1) 14%
• Leukemia Patients 14%
• Cyclin-dependent Kinase 6 (CDK6) 14%
• Transcriptional Network 14%
• Transcript Level 14%
• Oncogenic Proteins 14%
• Ubiquitin-proteasome System 14%
• Small Molecules 14%
• Adult Acute Lymphoblastic Leukemia 14%
• Off-target Effects 14%
• Preclinical Development 14%
• Fusion Transcript 14%
• CC-90009 14%
• Cereblon 14%
• Innovative Technologies 14%
• Heterobifunctional 14%
• Leukemia Subtypes 14%
• Ex Vivo Experiment 14%

Biochemistry, Genetics and Molecular Biology

• Myeloid 100%
• Fusion Gene 100%
• Proteolysis 100%
• Pediatrics 42%
• RUNX1 28%
• RUNX1T1 28%
• FUS 28%
• Tumor Progression 14%
• Carcinogenesis 14%
• Cell Cycle Arrest 14%
• Transcription Factor RUNX1 14%
• Small Molecule 14%
• Cell Cycle Checkpoint 14%
• Transcription Factor ERG 14%
• Fusion Transcript 14%
• Programmed Cell Death 14%
• Cereblon 14%