TY - JOUR
T1 - Pump speed optimization in stable patients with a left ventricular assist device
AU - Couperus, Lotte E.
AU - Delgado, Victoria
AU - Khidir, Mand J.H.
AU - Vester, Marijke P.M.
AU - Palmen, Meindert
AU - Fiocco, Marta
AU - Holman, Eduard R.
AU - Tops, Laurens F.
AU - Klautz, Robert J.M.
AU - Verwey, Harriëtte F.
AU - Schalij, Martin J.
AU - Beeres, Saskia L.M.A.
N1 - Publisher Copyright:
© 2017 by the ASAIO.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients, Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored, Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test, Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed, In 8 patients (47%), LVAD speed could be optimized, In these patients, RV fractional area change (26% [IQR 23-31] to 35% [IQR 27-45], p = 0.04) and RV longitudinal peak systolic strain (-13% [IQR -16 to -9] to -17% [IQR -18 to -11], p = 0.02) at 3 months follow-up improved without RV dilatation, Furthermore, N-terminal pro-brain natriuretic peptide level decreased (3,162 [IQR 1,336-4,487] ng/L to 2,294 [IQR 1,157-3,810] ng/L, p = 0.02),
AB - Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients, Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored, Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test, Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed, In 8 patients (47%), LVAD speed could be optimized, In these patients, RV fractional area change (26% [IQR 23-31] to 35% [IQR 27-45], p = 0.04) and RV longitudinal peak systolic strain (-13% [IQR -16 to -9] to -17% [IQR -18 to -11], p = 0.02) at 3 months follow-up improved without RV dilatation, Furthermore, N-terminal pro-brain natriuretic peptide level decreased (3,162 [IQR 1,336-4,487] ng/L to 2,294 [IQR 1,157-3,810] ng/L, p = 0.02),
KW - Left ventricular assist device
KW - Pump speed
KW - Right ventricular function
UR - http://www.scopus.com/inward/record.url?scp=85002251379&partnerID=8YFLogxK
U2 - 10.1097/MAT.0000000000000483
DO - 10.1097/MAT.0000000000000483
M3 - Article
C2 - 27922889
AN - SCOPUS:85002251379
SN - 1058-2916
VL - 63
SP - 266
EP - 272
JO - ASAIO Journal
JF - ASAIO Journal
IS - 3
ER -