TY - JOUR
T1 - Recent advancements in diffusion MRI for investigating cortical development after preterm birth—potential and pitfalls
AU - Dudink, J.
AU - Pieterman, K.
AU - Leemans, A.
AU - Kleinnijenhuis, M.
AU - van Cappellen van Walsum, A. M.
AU - Hoebeek, F. E.
N1 - Publisher Copyright:
© 2015 Dudink, Pieterman, Leemans, Kleinnijenhuis, van Cappellen van Walsum and Hoebeek.
PY - 2015/1/21
Y1 - 2015/1/21
N2 - Preterm infants are born during a critical period of brain maturation, in which even subtle events can result in substantial behavioral, motor and cognitive deficits, as well as psychiatric diseases. Recent evidence shows that the main source for these devastating disabilities is not necessarily white matter (WM) damage but could also be disruptions of cortical microstructure. Animal studies showed how moderate hypoxic-ischemic conditions did not result in significant neuronal loss in the developing brain, but did cause significantly impaired dendritic growth and synapse formation alongside a disturbed development of neuronal connectivity as measured using diffusion magnetic resonance imaging (dMRI). When using more advanced acquisition settings such as high-angular resolution diffusion imaging (HARDI), more advanced reconstruction methods can be applied to investigate the cortical microstructure with higher levels of detail. Recent advances in dMRI acquisition and analysis have great potential to contribute to a better understanding of neuronal connectivity impairment in preterm birth. We will review the current understanding of abnormal preterm cortical development, novel approaches in dMRI, and the pitfalls in scanning vulnerable preterm infants.
AB - Preterm infants are born during a critical period of brain maturation, in which even subtle events can result in substantial behavioral, motor and cognitive deficits, as well as psychiatric diseases. Recent evidence shows that the main source for these devastating disabilities is not necessarily white matter (WM) damage but could also be disruptions of cortical microstructure. Animal studies showed how moderate hypoxic-ischemic conditions did not result in significant neuronal loss in the developing brain, but did cause significantly impaired dendritic growth and synapse formation alongside a disturbed development of neuronal connectivity as measured using diffusion magnetic resonance imaging (dMRI). When using more advanced acquisition settings such as high-angular resolution diffusion imaging (HARDI), more advanced reconstruction methods can be applied to investigate the cortical microstructure with higher levels of detail. Recent advances in dMRI acquisition and analysis have great potential to contribute to a better understanding of neuronal connectivity impairment in preterm birth. We will review the current understanding of abnormal preterm cortical development, novel approaches in dMRI, and the pitfalls in scanning vulnerable preterm infants.
KW - Cortical development
KW - Cortical development and plasticity
KW - Cortical imaging technique
KW - Diffusion magnetic resonance imaging
KW - Diffusion MRI
KW - DTI
KW - Prematurity
UR - http://www.scopus.com/inward/record.url?scp=84937548333&partnerID=8YFLogxK
U2 - 10.3389/fnhum.2014.01066
DO - 10.3389/fnhum.2014.01066
M3 - Review article
AN - SCOPUS:84937548333
SN - 1662-5161
VL - 8
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
IS - JAN
M1 - 1066
ER -