Receptor subtype discrimination using extensive shape complementary designed interfaces

Keyphrases

• Antagonism 50%
• Binder 50%
• Complementary Interaction 50%
• Complementary Interfaces 50%
• Computational Design 50%
• Design Selection 50%
• Drug Discovery 50%
• Experimental Selection 50%
• Frizzled 100%
• Functional Site 50%
• In Vivo Applications 50%
• Interaction Surface 50%
• Intestinal Crypt Stem Cell 50%
• Liver Gene Expression 50%
• Pericentral 50%
• Protein Family 50%
• Protein Surface 50%
• Random Library 50%
• Receptor Subtypes 100%
• Relevant Region 50%
• Repeat Proteins 100%
• Selection Strategy 50%
• Selective Antagonist 50%
• Sequence Difference 50%
• Stem Cell Compartment 50%
• Subtype Discrimination 100%
• Subtype Selectivity 50%
• Subtype-specific 50%

Biochemistry, Genetics and Molecular Biology

• Drug Development 50%
• Frizzled 100%
• Gene Expression 50%
• Protein Family 50%
• Repeat Protein 100%
• Stem Cell 50%

Neuroscience

• Frizzled 100%
• Gene Expression 50%
• In Vivo 50%
• Protein Family 50%
• Receptor Subtype 100%
• Stem Cell 50%