Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers; Peter van Mourik; Annelotte M. Vonk; Evelien Kruisselbrink; Johanna F. Dekkers; Karin M. de Winter-de Groot; Hubertus G.M. Arets; Rozemarijn E.P. Marck-van der Wilt; Jasper S. Dijkema; Maaike M. Vanderschuren; Roderick H.J. Houwen; Harry G.M. Heijerman; Eduard A. van de Graaf; Sjoerd G. Elias; Christof J. Majoor; Gerard H. Koppelman; Jolt Roukema; Marleen Bakker; Hettie M. Janssens; Renske van der Meer; Robert G.J. Vries; Hans C. Clevers; Hugo R. de Jonge; Jeffrey M. Beekman; Cornelis K. van der Ent

doi:10.1016/j.celrep.2019.01.068

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers
, Peter van Mourik
, Annelotte M. Vonk
, Evelien Kruisselbrink
, Johanna F. Dekkers
, Karin M. de Winter-de Groot
, Hubertus G.M. Arets
, Rozemarijn E.P. Marck-van der Wilt
, Jasper S. Dijkema
, Maaike M. Vanderschuren
, Roderick H.J. Houwen
, Harry G.M. Heijerman
, Eduard A. van de Graaf
, Sjoerd G. Elias
, Christof J. Majoor
, Gerard H. Koppelman
, Jolt Roukema
, Marleen Bakker
, Hettie M. Janssens
, Renske van der Meer

Robert G.J. Vries, Hans C. Clevers, Hugo R. de Jonge, Jeffrey M. Beekman, Cornelis K. van der Ent

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

251 Citaten (Scopus)

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Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

Originele taal-2	Engels
Pagina's (van-tot)	1701-1708.e3
Tijdschrift	Cell reports
Volume	26
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1016/j.celrep.2019.01.068
Status	Gepubliceerd - 12 feb. 2019
Extern gepubliceerd	Ja

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10.1016/j.celrep.2019.01.068

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Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., Houwen, R. H. J., Heijerman, H. G. M., van de Graaf, E. A., Elias, S. G., Majoor, C. J., Koppelman, G. H., Roukema, J., Bakker, M., Janssens, H. M., ... van der Ent, C. K. (2019). Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. Cell reports, 26(7), 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068

@article{79f9f585d90340eaa9f37c19e80e47ee,

title = "Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis",

abstract = "Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.",

keywords = "CFTR, cystic fibrosis, drug response, organoids, personalized treatment, predicting, stem cell cultures",

author = "Gitte Berkers and \{van Mourik\}, Peter and Vonk, \{Annelotte M.\} and Evelien Kruisselbrink and Dekkers, \{Johanna F.\} and \{de Winter-de Groot\}, \{Karin M.\} and Arets, \{Hubertus G.M.\} and \{Marck-van der Wilt\}, \{Rozemarijn E.P.\} and Dijkema, \{Jasper S.\} and Vanderschuren, \{Maaike M.\} and Houwen, \{Roderick H.J.\} and Heijerman, \{Harry G.M.\} and \{van de Graaf\}, \{Eduard A.\} and Elias, \{Sjoerd G.\} and Majoor, \{Christof J.\} and Koppelman, \{Gerard H.\} and Jolt Roukema and Marleen Bakker and Janssens, \{Hettie M.\} and \{van der Meer\}, Renske and Vries, \{Robert G.J.\} and Clevers, \{Hans C.\} and \{de Jonge\}, \{Hugo R.\} and Beekman, \{Jeffrey M.\} and \{van der Ent\}, \{Cornelis K.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = feb,

day = "12",

doi = "10.1016/j.celrep.2019.01.068",

language = "English",

volume = "26",

pages = "1701--1708.e3",

journal = "Cell reports",

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Berkers, G, van Mourik, P, Vonk, AM, Kruisselbrink, E, Dekkers, JF, de Winter-de Groot, KM, Arets, HGM, Marck-van der Wilt, REP, Dijkema, JS, Vanderschuren, MM, Houwen, RHJ, Heijerman, HGM, van de Graaf, EA, Elias, SG, Majoor, CJ, Koppelman, GH, Roukema, J, Bakker, M, Janssens, HM, van der Meer, R, Vries, RGJ, Clevers, HC, de Jonge, HR, Beekman, JM & van der Ent, CK 2019, 'Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis', Cell reports, vol. 26, nr. 7, blz. 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068

TY - JOUR

T1 - Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

AU - Berkers, Gitte

AU - van Mourik, Peter

AU - Vonk, Annelotte M.

AU - Kruisselbrink, Evelien

AU - Dekkers, Johanna F.

AU - de Winter-de Groot, Karin M.

AU - Arets, Hubertus G.M.

AU - Marck-van der Wilt, Rozemarijn E.P.

AU - Dijkema, Jasper S.

AU - Vanderschuren, Maaike M.

AU - Houwen, Roderick H.J.

AU - Heijerman, Harry G.M.

AU - van de Graaf, Eduard A.

AU - Elias, Sjoerd G.

AU - Majoor, Christof J.

AU - Koppelman, Gerard H.

AU - Roukema, Jolt

AU - Bakker, Marleen

AU - Janssens, Hettie M.

AU - van der Meer, Renske

AU - Vries, Robert G.J.

AU - Clevers, Hans C.

AU - de Jonge, Hugo R.

AU - Beekman, Jeffrey M.

AU - van der Ent, Cornelis K.

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

AB - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

KW - CFTR

KW - cystic fibrosis

KW - drug response

KW - organoids

KW - personalized treatment

KW - predicting

KW - stem cell cultures

UR - https://www.scopus.com/pages/publications/85061162213

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DO - 10.1016/j.celrep.2019.01.068

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C2 - 30759382

AN - SCOPUS:85061162213

SN - 2211-1247

VL - 26

SP - 1701-1708.e3

JO - Cell reports

JF - Cell reports

IS - 7

ER -

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

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