TY - JOUR
T1 - Reduced versus intensive chemotherapy for childhood acute lymphoblastic leukemia
T2 - Impact on lymphocyte compartment composition
AU - Van Tilburg, Cornelis M.
AU - van der Velden, Vincent H.J.
AU - Sanders, Elisabeth A.M.
AU - Wolfs, Tom F.W.
AU - Gaiser, Jacobus F.
AU - de Haas, Valerie
AU - Pieters, Rob
AU - Bloem, Andries C.
AU - Bierings, Marc B.
N1 - Funding Information:
This work was financially supported by an unrestricted grant of KiKa foundation (Children Free of Cancer foundation), The Netherlands . The sponsor had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
PY - 2011/4
Y1 - 2011/4
N2 - Chemotherapy for childhood acute lymphoblastic leukemia may cause severe immune damage. The lymphocyte compartment of 140 patients during and after a new strongly reduced (standard risk (SR), n=43) and intensive chemotherapy regimen (medium risk (MR), n=97) was studied between 2006 and 2009. Transitional and naive B cells and IgG+/A+, IgM+ and IgM only memory B cells were significantly reduced during chemotherapy; significantly more in MR group. One year after treatment CD27+IgG+/A+, IgM+ and IgM only memory B cells had still not fully recovered, but this was not confined to the MR group. The T cell compartment was less but also significantly affected during chemotherapy and recovered to normal levels. In the MR group, NK cells had not fully recovered to normal levels 1 year after treatment. Thus, intensive chemotherapy regimens cause severe, mainly B cell memory damage that persists even 1 year after treatment.
AB - Chemotherapy for childhood acute lymphoblastic leukemia may cause severe immune damage. The lymphocyte compartment of 140 patients during and after a new strongly reduced (standard risk (SR), n=43) and intensive chemotherapy regimen (medium risk (MR), n=97) was studied between 2006 and 2009. Transitional and naive B cells and IgG+/A+, IgM+ and IgM only memory B cells were significantly reduced during chemotherapy; significantly more in MR group. One year after treatment CD27+IgG+/A+, IgM+ and IgM only memory B cells had still not fully recovered, but this was not confined to the MR group. The T cell compartment was less but also significantly affected during chemotherapy and recovered to normal levels. In the MR group, NK cells had not fully recovered to normal levels 1 year after treatment. Thus, intensive chemotherapy regimens cause severe, mainly B cell memory damage that persists even 1 year after treatment.
KW - Acute lymphoblastic leukemia
KW - B-lymphocyte subsets
KW - Child
KW - Immunologic memory
KW - T-lymphocyte subsets
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=79952362868&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2010.10.005
DO - 10.1016/j.leukres.2010.10.005
M3 - Article
C2 - 21051085
AN - SCOPUS:79952362868
SN - 0145-2126
VL - 35
SP - 484
EP - 491
JO - Leukemia Research
JF - Leukemia Research
IS - 4
ER -