Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

Joep Beumer, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

204 Citaten (Scopus)


The intestinal epithelium is the fastest renewing tissue in mammals and has a large flexibility to adapt to different types of damage. Lgr5+ crypt base columnar (CBC) cells act as stem cells during homeostasis and are essential during regeneration. Upon perturbation, the activity of CBCs is dynamically regulated to maintain homeostasis and multiple dedicated progenitor cell populations can reverse to the stem cell state upon damage, adding another layer of compensatory mechanisms to facilitate regeneration. Here, we review our current understanding of how intestinal stem and progenitor cells contribute to homeostasis and regeneration, and the different signaling pathways that regulate their behavior. Nutritional state and inflammation have been recently identified as upstream regulators of stem cell activity in the mammalian intestine, and we explore how these systemic signals can influence homeostasis and regeneration.

Originele taal-2Engels
Pagina's (van-tot)3639-3649
Aantal pagina's11
Nummer van het tijdschrift20
StatusGepubliceerd - 15 okt. 2016
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Regulation and plasticity of intestinal stem cells during homeostasis and regeneration'. Samen vormen ze een unieke vingerafdruk.

Citeer dit