Regulation of cerebral cortex size and folding by expansion of basal progenitors

Miki Nonaka-Kinoshita, Isabel Reillo, Benedetta Artegiani, Maria Ángeles Martínez-Martínez, Mark Nelson, Víctor Borrell, Federico Calegari

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

182 Citaten (Scopus)


Size and folding of the cerebral cortex increased massively during mammalian evolution leading to the current diversity of brain morphologies. Various subtypes of neural stem and progenitor cells have been proposed to contribute differently in regulating thickness or folding of the cerebral cortex during development, but their specific roles have not been demonstrated. We report that the controlled expansion of unipotent basal progenitors in mouse embryos led to megalencephaly, with increased surface area of the cerebral cortex, but not to cortical folding. In contrast, expansion of multipotent basal progenitors in the naturally gyrencephalic ferret was sufficient to drive the formation of additional folds and fissures. In both models, changes occurred while preserving a structurally normal, six-layered cortex. Our results are the first experimental demonstration of specific and distinct roles for basal progenitor subtypes in regulating cerebral cortex size and folding during development underlying the superior intellectual capability acquired by higher mammals during evolution.

Originele taal-2Engels
Pagina's (van-tot)1817-28
Aantal pagina's12
TijdschriftThe EMBO journal
Nummer van het tijdschrift13
StatusGepubliceerd - 3 jul. 2013
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Regulation of cerebral cortex size and folding by expansion of basal progenitors'. Samen vormen ze een unieke vingerafdruk.

Citeer dit