TY - JOUR
T1 - Relapsed rhabdoid tumours and other non-nephroblastoma childhood and adolescent kidney tumours
T2 - perspectives from the HARMONICA collaboration
AU - Ortiz, Michael V.
AU - Wens, Francis S.P.L.
AU - Hong, Andrew L.
AU - Quarello, Paola
AU - Verschuur, Arnauld C.
AU - Tracy, Elisabeth T.
AU - Daw, Najat C.
AU - Dome, Jeffrey S.
AU - Walz, Amy L.
AU - Sprokkerieft, Julia
AU - Tytgat, Godelieve A.M.
AU - Kentsis, Alex
AU - Libes-Bander, Jaime
AU - Schoettler, Peter J.
AU - Perotti, Daniela
AU - Drost, Jarno
AU - Venkatramani, Rajkumar
AU - Geller, James I.
AU - van den Heuvel-Eibrink, Marry M.
N1 - Publisher Copyright:
© Springer Nature Limited 2026.
PY - 2026/1/2
Y1 - 2026/1/2
N2 - Paediatric kidney tumours are generally associated with a favourable survival rate. Most children are diagnosed with Wilms tumour, which has a 90% long-term survival rate with conventional front-line and salvage therapies. However, treatments and outcomes of children with relapsed non-Wilms tumours, such as malignant rhabdoid tumour of the kidney, renal-cell carcinoma (including renal medullary carcinoma), clear-cell sarcoma of the kidney, anaplastic sarcoma of the kidney and congenital mesoblastic nephroma are not well defined. Several of these non-Wilms tumours include unfavourable prognostic subtypes. Currently available data on non-Wilms tumours support advancing studies that pivot from conventional strategies towards disease-specific, biologically driven novel treatments to improve outcomes for each of these rare childhood kidney tumours.
AB - Paediatric kidney tumours are generally associated with a favourable survival rate. Most children are diagnosed with Wilms tumour, which has a 90% long-term survival rate with conventional front-line and salvage therapies. However, treatments and outcomes of children with relapsed non-Wilms tumours, such as malignant rhabdoid tumour of the kidney, renal-cell carcinoma (including renal medullary carcinoma), clear-cell sarcoma of the kidney, anaplastic sarcoma of the kidney and congenital mesoblastic nephroma are not well defined. Several of these non-Wilms tumours include unfavourable prognostic subtypes. Currently available data on non-Wilms tumours support advancing studies that pivot from conventional strategies towards disease-specific, biologically driven novel treatments to improve outcomes for each of these rare childhood kidney tumours.
UR - https://www.scopus.com/pages/publications/105026390577
UR - https://www.mendeley.com/catalogue/a058fef6-e3e9-326e-87f8-e676710d80f3/
U2 - 10.1038/s41585-025-01117-4
DO - 10.1038/s41585-025-01117-4
M3 - Review article
C2 - 41478859
SN - 1759-4812
JO - Nature reviews. Urology
JF - Nature reviews. Urology
ER -