Raphael L. Yechieli, Henry C. Mandeville, Susan M. Hiniker, Valerie Bernier-Chastagner, Susan McGovern, Giovanni Scarzello, Suzanne Wolden, Alison Cameron, John Breneman, Raquel Davila Fajardo, Sarah S. Donaldson

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

12 Citaten (Scopus)


Rhabdomyosarcoma is a heterogeneous disease both in presentation and histology. Improvements in a multimodality therapy resulted in the improved overall survival for patients with a low-risk and intermediate-risk disease but not for patients with a metastatic disease. We reviewed and contrasted the North American and European practice patterns, though ultimately the principles of staging, surgery, radiation therapy, and chemotherapy are similar in both Children's Oncology Group and International Society of Paediatric Oncology treatment approaches. Efforts are underway to investigate improved local control rates in higher risk patients using radiation dose escalation strategies, and delayed primary excision in select cases. The prognostic significance of imaging-based chemotherapy response, proton therapy, novel biomarkers, and targeted drugs will be determined in upcoming clinical trials.

Originele taal-2Engels
TijdschriftPediatric Blood and Cancer
Nummer van het tijdschriftS2
StatusGepubliceerd - mei 2021
Extern gepubliceerdJa


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