Samenvatting
Mannose-binding lectin (MBL)-deficient children with cancer may benefit from substitution of the innate immune protein MBL during chemotherapy-induced neutropaenia. We determined the safety and pharmacokinetics of MBL substitution in a phase II study in MBL-deficient children. Twelve MBL-deficient children with cancer (aged 0-12 years) received infusions of plasma-derived MBL once, or twice weekly during a chemotherapy-induced neutropaenic episode (range: 1-4 weeks). Four patients participated multiple times. Target levels of 1.0 μg/ml were considered therapeutic. In total, 65 MBL infusions were given. No MBL-related adverse reactions were observed, and the observed trough level was 1.06 μg/ml (range: 0.66-2.05 μg/ml). Pharmacokinetics were not related to age after correction for body weight. The half-life of MBL, for a child of 25 kg, was 36.4 h (range: 23.7-66.6 h). No anti-MBL antibodies were measured 4 weeks after each MBL course. Substitution therapy with MBL-SSI twice weekly was safe and resulted in trough levels considered protective.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 505-512 |
Aantal pagina's | 8 |
Tijdschrift | European Journal of Cancer |
Volume | 45 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Gepubliceerd - mrt. 2009 |
Extern gepubliceerd | Ja |