Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen; Annelies Mavinkurve-Groothuis; Karin Kamphuis-Van Ulzen; Roger Brüggemann; Paul Verweij; Adilia Warris

doi:10.1016/j.mmcr.2014.02.001

Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen, Annelies Mavinkurve-Groothuis, Karin Kamphuis-Van Ulzen, Roger Brüggemann, Paul Verweij, Adilia Warris

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

15 Citaten (Scopus)

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The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

Originele taal-2	Engels
Pagina's (van-tot)	8-11
Aantal pagina's	4
Tijdschrift	Medical Mycology Case Reports
Volume	4
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.mmcr.2014.02.001
Status	Gepubliceerd - apr. 2014
Extern gepubliceerd	Ja

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title = "Screening of the central nervous system in children with invasive pulmonary aspergillosis",

abstract = "The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.",

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AU - Kamphuis-Van Ulzen, Karin

AU - Brüggemann, Roger

AU - Verweij, Paul

AU - Warris, Adilia

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AB - The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

KW - Aspergillosis

KW - Central nervous system

KW - Pediatrics

KW - Screening

KW - Therapeutic drug monitoring

KW - Voriconazole

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Screening of the central nervous system in children with invasive pulmonary aspergillosis

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