Secondary and tertiary structure modeling reveals effects of novel mutations in polycystic liver disease genes PRKCSH and SEC63

Keyphrases

• Disease Genes 100%
• Novel mutation 100%
• PRKCSH 100%
• Sec63 100%
• Polycystic Liver Disease 100%
• Secondary Structure 100%
• Tertiary Structure Modeling 100%
• Two-component Domains 20%
• Missense mutation 20%
• Splicing mutation 20%
• Nonsense mutation 20%
• Liver 20%
• Protein Function 20%
• Proband 20%
• Evolutionary Conservation 20%
• Disease-causing mutations 20%
• In Silico Analysis 20%
• Protein Structure 20%
• Highly Conserved Regions 20%
• Residue Substitutions 20%
• Homology Modeling 20%
• Secondary Structure Prediction 20%
• Insertion-deletion 20%
• Sift 20%
• Bile Duct Cyst 20%
• Capillary Electrophoresis 20%
• Conservation Structures 20%
• Splice Site Recognition 20%
• Tertiary Structure Prediction 20%
• Direct Sequencing 20%

Biochemistry, Genetics and Molecular Biology

• Tertiary Structure 100%
• Nonsense Mutation 50%
• Missense Mutation 50%
• Splice Site Mutation 50%
• Conformation 50%
• Genetic Conservation 50%
• Indel 50%
• Protein Structure 50%
• Proband 50%
• Capillary Electrophoresis 50%
• Homology Modeling 50%
• Hen 50%
• Structure Prediction 50%