Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma

Jorine De Haan; Johannes V. Van Thienen; Michael Casaer; Rebekka A. Hannivoort; Kristel Van Calsteren; Minke Van Tuyl; Mathilde M. Van Gerwen; Anne Debeer; Frédéric Amant; Rebecca C. Painter

doi:10.1159/000487128

Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma

Jorine De Haan, Johannes V. Van Thienen, Michael Casaer, Rebekka A. Hannivoort, Kristel Van Calsteren, Minke Van Tuyl, Mathilde M. Van Gerwen, Anne Debeer, Frédéric Amant, Rebecca C. Painter

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

20 Citaten (Scopus)

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Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.

Originele taal-2	Engels
Pagina's (van-tot)	119-124
Aantal pagina's	6
Tijdschrift	Case Reports in Oncology
Volume	11
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1159/000487128
Status	Gepubliceerd - 19 jan. 2018
Extern gepubliceerd	Ja

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title = "Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma",

abstract = "Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.",

keywords = "Metastatic melanoma, Pregnancy, Toxic epidermal necrolysis, Vemurafenib",

author = "{De Haan}, Jorine and {Van Thienen}, {Johannes V.} and Michael Casaer and Hannivoort, {Rebekka A.} and {Van Calsteren}, Kristel and {Van Tuyl}, Minke and {Van Gerwen}, {Mathilde M.} and Anne Debeer and Fr{\'e}d{\'e}ric Amant and Painter, {Rebecca C.}",

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doi = "10.1159/000487128",

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AU - De Haan, Jorine

AU - Van Thienen, Johannes V.

AU - Casaer, Michael

AU - Hannivoort, Rebekka A.

AU - Van Calsteren, Kristel

AU - Van Tuyl, Minke

AU - Van Gerwen, Mathilde M.

AU - Debeer, Anne

AU - Amant, Frédéric

AU - Painter, Rebecca C.

PY - 2018/1/19

Y1 - 2018/1/19

N2 - Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.

AB - Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.

KW - Metastatic melanoma

KW - Pregnancy

KW - Toxic epidermal necrolysis

KW - Vemurafenib

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Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma

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