Signaling Mucins in the (S)limelight

Hans Clevers

doi:10.1016/j.devcel.2004.07.013

Signaling Mucins in the (S)limelight

Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

5 Citaten (Scopus)

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Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

Originele taal-2	Engels
Pagina's (van-tot)	150-151
Aantal pagina's	2
Tijdschrift	Developmental Cell
Volume	7
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/j.devcel.2004.07.013
Status	Gepubliceerd - aug 2004
Extern gepubliceerd	Ja

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title = "Signaling Mucins in the (S)limelight",

abstract = "Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes \& Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.",

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AB - Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

UR - https://www.scopus.com/pages/publications/4344594045

U2 - 10.1016/j.devcel.2004.07.013

DO - 10.1016/j.devcel.2004.07.013

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JO - Developmental Cell

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Signaling Mucins in the (S)limelight

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