Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo; Bernhard Englinger; Li Jiang; Jens M. Hübner; McKenzie L. Shaw; Olivia A. Hack; Sibylle Madlener; Dominik Kirchhofer; Ilon Liu; Jason Pyrdol; Volker Hovestadt; Emanuele Mazzola; Nathan D. Mathewson; Maria Trissal; Daniela Lötsch; Christian Dorfer; Christine Haberler; Angela Halfmann; Lisa Mayr; Andreas Peyrl; Rene Geyeregger; Benjamin Schwalm; Monica Mauermann; Kristian W. Pajtler; Till Milde; Marni E. Shore; Jack E. Geduldig; Kristine Pelton; Thomas Czech; Orr Ashenberg; Kai W. Wucherpfennig; Orit Rozenblatt-Rosen; Sanda Alexandrescu; Keith L. Ligon; Stefan M. Pfister; Aviv Regev; Irene Slavc; Walter Berger; Mario L. Suvà; Marcel Kool; Mariella G. Filbin

doi:10.1016/j.ccell.2020.06.004

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo, Bernhard Englinger, Li Jiang, Jens M. Hübner, McKenzie L. Shaw, Olivia A. Hack, Sibylle Madlener, Dominik Kirchhofer, Ilon Liu, Jason Pyrdol, Volker Hovestadt, Emanuele Mazzola, Nathan D. Mathewson, Maria Trissal, Daniela Lötsch, Christian Dorfer, Christine Haberler, Angela Halfmann, Lisa Mayr, Andreas PeyrlRene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler, Till Milde, Marni E. Shore, Jack E. Geduldig, Kristine Pelton, Thomas Czech, Orr Ashenberg, Kai W. Wucherpfennig, Orit Rozenblatt-Rosen, Sanda Alexandrescu, Keith L. Ligon, Stefan M. Pfister, Aviv Regev, Irene Slavc, Walter Berger, Mario L. Suvà, Marcel Kool, Mariella G. Filbin

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Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

Originele taal-2	Engels
Pagina's (van-tot)	44-59.e9
Tijdschrift	Cancer Cell
Volume	38
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.ccell.2020.06.004
Status	Gepubliceerd - 13 jul. 2020

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Gojo, J., Englinger, B., Jiang, L., Hübner, J. M., Shaw, M. L., Hack, O. A., Madlener, S., Kirchhofer, D., Liu, I., Pyrdol, J., Hovestadt, V., Mazzola, E., Mathewson, N. D., Trissal, M., Lötsch, D., Dorfer, C., Haberler, C., Halfmann, A., Mayr, L., ... Filbin, M. G. (2020). Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell, 38(1), 44-59.e9. https://doi.org/10.1016/j.ccell.2020.06.004

@article{40c7f97c5e7940f796d7106e31711daa,

title = "Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma",

abstract = "Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.",

keywords = "aberrant development, cancer stem cells, cellular hierarchy, differentiation trajectory, EPN, glial development, intratumoral heterogeneity, Pediatric ependymoma, single-cell RNA sequencing, target identification",

author = "Johannes Gojo and Bernhard Englinger and Li Jiang and H{\"u}bner, {Jens M.} and Shaw, {McKenzie L.} and Hack, {Olivia A.} and Sibylle Madlener and Dominik Kirchhofer and Ilon Liu and Jason Pyrdol and Volker Hovestadt and Emanuele Mazzola and Mathewson, {Nathan D.} and Maria Trissal and Daniela L{\"o}tsch and Christian Dorfer and Christine Haberler and Angela Halfmann and Lisa Mayr and Andreas Peyrl and Rene Geyeregger and Benjamin Schwalm and Monica Mauermann and Pajtler, {Kristian W.} and Till Milde and Shore, {Marni E.} and Geduldig, {Jack E.} and Kristine Pelton and Thomas Czech and Orr Ashenberg and Wucherpfennig, {Kai W.} and Orit Rozenblatt-Rosen and Sanda Alexandrescu and Ligon, {Keith L.} and Pfister, {Stefan M.} and Aviv Regev and Irene Slavc and Walter Berger and Suv{\`a}, {Mario L.} and Marcel Kool and Filbin, {Mariella G.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = jul,

day = "13",

doi = "10.1016/j.ccell.2020.06.004",

language = "English",

volume = "38",

pages = "44--59.e9",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "1",

}

Gojo, J, Englinger, B, Jiang, L, Hübner, JM, Shaw, ML, Hack, OA, Madlener, S, Kirchhofer, D, Liu, I, Pyrdol, J, Hovestadt, V, Mazzola, E, Mathewson, ND, Trissal, M, Lötsch, D, Dorfer, C, Haberler, C, Halfmann, A, Mayr, L, Peyrl, A, Geyeregger, R, Schwalm, B, Mauermann, M, Pajtler, KW, Milde, T, Shore, ME, Geduldig, JE, Pelton, K, Czech, T, Ashenberg, O, Wucherpfennig, KW, Rozenblatt-Rosen, O, Alexandrescu, S, Ligon, KL, Pfister, SM, Regev, A, Slavc, I, Berger, W, Suvà, ML, Kool, M & Filbin, MG 2020, 'Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma', Cancer Cell, vol. 38, nr. 1, blz. 44-59.e9. https://doi.org/10.1016/j.ccell.2020.06.004

TY - JOUR

T1 - Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

AU - Gojo, Johannes

AU - Englinger, Bernhard

AU - Jiang, Li

AU - Hübner, Jens M.

AU - Shaw, McKenzie L.

AU - Hack, Olivia A.

AU - Madlener, Sibylle

AU - Kirchhofer, Dominik

AU - Liu, Ilon

AU - Pyrdol, Jason

AU - Hovestadt, Volker

AU - Mazzola, Emanuele

AU - Mathewson, Nathan D.

AU - Trissal, Maria

AU - Lötsch, Daniela

AU - Dorfer, Christian

AU - Haberler, Christine

AU - Halfmann, Angela

AU - Mayr, Lisa

AU - Peyrl, Andreas

AU - Geyeregger, Rene

AU - Schwalm, Benjamin

AU - Mauermann, Monica

AU - Pajtler, Kristian W.

AU - Milde, Till

AU - Shore, Marni E.

AU - Geduldig, Jack E.

AU - Pelton, Kristine

AU - Czech, Thomas

AU - Ashenberg, Orr

AU - Wucherpfennig, Kai W.

AU - Rozenblatt-Rosen, Orit

AU - Alexandrescu, Sanda

AU - Ligon, Keith L.

AU - Pfister, Stefan M.

AU - Regev, Aviv

AU - Slavc, Irene

AU - Berger, Walter

AU - Suvà, Mario L.

AU - Kool, Marcel

AU - Filbin, Mariella G.

PY - 2020/7/13

Y1 - 2020/7/13

N2 - Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

AB - Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

KW - aberrant development

KW - cancer stem cells

KW - cellular hierarchy

KW - differentiation trajectory

KW - EPN

KW - glial development

KW - intratumoral heterogeneity

KW - Pediatric ependymoma

KW - single-cell RNA sequencing

KW - target identification

UR - http://www.scopus.com/inward/record.url?scp=85087480039&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2020.06.004

DO - 10.1016/j.ccell.2020.06.004

M3 - Article

C2 - 32663469

AN - SCOPUS:85087480039

SN - 1535-6108

VL - 38

SP - 44-59.e9

JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

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