Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo; Bernhard Englinger; Li Jiang; Jens M. Hübner; McKenzie L. Shaw; Olivia A. Hack; Sibylle Madlener; Dominik Kirchhofer; Ilon Liu; Jason Pyrdol; Volker Hovestadt; Emanuele Mazzola; Nathan D. Mathewson; Maria Trissal; Daniela Lötsch; Christian Dorfer; Christine Haberler; Angela Halfmann; Lisa Mayr; Andreas Peyrl; Rene Geyeregger; Benjamin Schwalm; Monica Mauermann; Kristian W. Pajtler; Till Milde; Marni E. Shore; Jack E. Geduldig; Kristine Pelton; Thomas Czech; Orr Ashenberg; Kai W. Wucherpfennig; Orit Rozenblatt-Rosen; Sanda Alexandrescu; Keith L. Ligon; Stefan M. Pfister; Aviv Regev; Irene Slavc; Walter Berger; Mario L. Suvà; Marcel Kool; Mariella G. Filbin

doi:10.1016/j.ccell.2020.06.004

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo
, Bernhard Englinger
, Li Jiang
, Jens M. Hübner
, McKenzie L. Shaw
, Olivia A. Hack
, Sibylle Madlener
, Dominik Kirchhofer
, Ilon Liu
, Jason Pyrdol
, Volker Hovestadt
, Emanuele Mazzola
, Nathan D. Mathewson
, Maria Trissal
, Daniela Lötsch
, Christian Dorfer
, Christine Haberler
, Angela Halfmann
, Lisa Mayr
, Andreas Peyrl

Rene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler, Till Milde, Marni E. Shore, Jack E. Geduldig, Kristine Pelton, Thomas Czech, Orr Ashenberg, Kai W. Wucherpfennig, Orit Rozenblatt-Rosen, Sanda Alexandrescu, Keith L. Ligon, Stefan M. Pfister, Aviv Regev, Irene Slavc, Walter Berger, Mario L. Suvà, Marcel Kool, Mariella G. Filbin

Group Kool

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

131 Citaten (Scopus)

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Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

Originele taal-2	Engels
Pagina's (van-tot)	44-59.e9
Tijdschrift	Cancer Cell
Volume	38
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.ccell.2020.06.004
Status	Gepubliceerd - 13 jul 2020

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10.1016/j.ccell.2020.06.004

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Gojo, J., Englinger, B., Jiang, L., Hübner, J. M., Shaw, M. L., Hack, O. A., Madlener, S., Kirchhofer, D., Liu, I., Pyrdol, J., Hovestadt, V., Mazzola, E., Mathewson, N. D., Trissal, M., Lötsch, D., Dorfer, C., Haberler, C., Halfmann, A., Mayr, L., ... Filbin, M. G. (2020). Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell, 38(1), 44-59.e9. https://doi.org/10.1016/j.ccell.2020.06.004

@article{40c7f97c5e7940f796d7106e31711daa,

title = "Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma",

abstract = "Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.",

keywords = "EPN, Pediatric ependymoma, aberrant development, cancer stem cells, cellular hierarchy, differentiation trajectory, glial development, intratumoral heterogeneity, single-cell RNA sequencing, target identification",

author = "Johannes Gojo and Bernhard Englinger and Li Jiang and H{\"u}bner, \{Jens M.\} and Shaw, \{McKenzie L.\} and Hack, \{Olivia A.\} and Sibylle Madlener and Dominik Kirchhofer and Ilon Liu and Jason Pyrdol and Volker Hovestadt and Emanuele Mazzola and Mathewson, \{Nathan D.\} and Maria Trissal and Daniela L{\"o}tsch and Christian Dorfer and Christine Haberler and Angela Halfmann and Lisa Mayr and Andreas Peyrl and Rene Geyeregger and Benjamin Schwalm and Monica Mauermann and Pajtler, \{Kristian W.\} and Till Milde and Shore, \{Marni E.\} and Geduldig, \{Jack E.\} and Kristine Pelton and Thomas Czech and Orr Ashenberg and Wucherpfennig, \{Kai W.\} and Orit Rozenblatt-Rosen and Sanda Alexandrescu and Ligon, \{Keith L.\} and Pfister, \{Stefan M.\} and Aviv Regev and Irene Slavc and Walter Berger and Suv{\`a}, \{Mario L.\} and Marcel Kool and Filbin, \{Mariella G.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = jul,

day = "13",

doi = "10.1016/j.ccell.2020.06.004",

language = "English",

volume = "38",

pages = "44--59.e9",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "1",

}

Gojo, J, Englinger, B, Jiang, L, Hübner, JM, Shaw, ML, Hack, OA, Madlener, S, Kirchhofer, D, Liu, I, Pyrdol, J, Hovestadt, V, Mazzola, E, Mathewson, ND, Trissal, M, Lötsch, D, Dorfer, C, Haberler, C, Halfmann, A, Mayr, L, Peyrl, A, Geyeregger, R, Schwalm, B, Mauermann, M, Pajtler, KW, Milde, T, Shore, ME, Geduldig, JE, Pelton, K, Czech, T, Ashenberg, O, Wucherpfennig, KW, Rozenblatt-Rosen, O, Alexandrescu, S, Ligon, KL, Pfister, SM, Regev, A, Slavc, I, Berger, W, Suvà, ML, Kool, M & Filbin, MG 2020, 'Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma', Cancer Cell, vol. 38, nr. 1, blz. 44-59.e9. https://doi.org/10.1016/j.ccell.2020.06.004

TY - JOUR

T1 - Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

AU - Gojo, Johannes

AU - Englinger, Bernhard

AU - Jiang, Li

AU - Hübner, Jens M.

AU - Shaw, McKenzie L.

AU - Hack, Olivia A.

AU - Madlener, Sibylle

AU - Kirchhofer, Dominik

AU - Liu, Ilon

AU - Pyrdol, Jason

AU - Hovestadt, Volker

AU - Mazzola, Emanuele

AU - Mathewson, Nathan D.

AU - Trissal, Maria

AU - Lötsch, Daniela

AU - Dorfer, Christian

AU - Haberler, Christine

AU - Halfmann, Angela

AU - Mayr, Lisa

AU - Peyrl, Andreas

AU - Geyeregger, Rene

AU - Schwalm, Benjamin

AU - Mauermann, Monica

AU - Pajtler, Kristian W.

AU - Milde, Till

AU - Shore, Marni E.

AU - Geduldig, Jack E.

AU - Pelton, Kristine

AU - Czech, Thomas

AU - Ashenberg, Orr

AU - Wucherpfennig, Kai W.

AU - Rozenblatt-Rosen, Orit

AU - Alexandrescu, Sanda

AU - Ligon, Keith L.

AU - Pfister, Stefan M.

AU - Regev, Aviv

AU - Slavc, Irene

AU - Berger, Walter

AU - Suvà, Mario L.

AU - Kool, Marcel

AU - Filbin, Mariella G.

PY - 2020/7/13

Y1 - 2020/7/13

N2 - Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

AB - Gojo et al. use single-cell RNA sequencing to investigate intratumoral heterogeneity and cellular hierarchy in pediatric ependymoma, identifying impaired neurodevelopmental trajectories. The malignant trajectories reveal therapeutic targets and prognostic signatures in ependymoma.

KW - EPN

KW - Pediatric ependymoma

KW - aberrant development

KW - cancer stem cells

KW - cellular hierarchy

KW - differentiation trajectory

KW - glial development

KW - intratumoral heterogeneity

KW - single-cell RNA sequencing

KW - target identification

UR - https://www.scopus.com/pages/publications/85087480039

U2 - 10.1016/j.ccell.2020.06.004

DO - 10.1016/j.ccell.2020.06.004

M3 - Article

C2 - 32663469

AN - SCOPUS:85087480039

SN - 1535-6108

VL - 38

SP - 44-59.e9

JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

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