TY - JOUR
T1 - Skeletal Muscle Ultrasound
T2 - Correlation Between Fibrous Tissue and Echo Intensity
AU - Pillen, Sigrid
AU - Tak, Ramon O.
AU - Zwarts, Machiel J.
AU - Lammens, Martin M.Y.
AU - Verrijp, Kiek N.
AU - Arts, Ilse M.P.
AU - van der Laak, Jeroen A.
AU - Hoogerbrugge, Peter M.
AU - van Engelen, Baziel G.M.
AU - Verrips, Aad
N1 - Funding Information:
The authors thank the University of Missouri for providing the GRMD carrier dam and semen and Nens van Alfen, MD, PhD, for her critical reading of the manuscript. The study was supported by a grant from the Prinses Beatrix Fonds (No. MAR02–0105) and a grant form The Netherlands Organization for Health Research and Development (ZonMw No. 907 to 00–057).
PY - 2009/3
Y1 - 2009/3
N2 - In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: [email protected]).
AB - In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) of 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87; p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present. We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: [email protected]).
KW - Dogs
KW - Duchenne muscular dystrophy
KW - Echo intensity
KW - Muscle
KW - Neuromuscular disorders
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=60249102686&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2008.09.016
DO - 10.1016/j.ultrasmedbio.2008.09.016
M3 - Article
C2 - 19081667
AN - SCOPUS:60249102686
SN - 0301-5629
VL - 35
SP - 443
EP - 446
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 3
ER -