Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

M. E. Belderbos, G. M. van Bleek, O. Levy, M. O. Blanken, M. L. Houben, L. Schuijff, J. L.L. Kimpen, L. Bont

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

133 Citaten (Scopus)

Samenvatting

Newborns are highly susceptible to infectious diseases, which may be due to impaired immune responses. This study aims to characterize the ontogeny of neonatal TLR-based innate immunity during the first month of life. Cellularity and Toll-like receptor (TLR) agonist-induced cytokine production were compared between cord blood obtained from healthy neonates born after uncomplicated gestation and delivery (n = 18), neonatal venous blood obtained at the age of one month (n = 96), and adult venous blood (n = 17). Cord blood TLR agonist-induced production of the Th1-polarizing cytokines IL-12p70 and IFN-α was generally impaired, but for TLR3, 7 and 9 agonists, rapidly increased to adult levels during the first month of life. In contrast, TLR4 demonstrated a slower maturation, with low LPS-induced IL-12p70 production and high IL-10 production up until the age of one month. Polarization in neonatal cytokine responses to LPS could contribute to neonatal susceptibility to severe bacterial infection.

Originele taal-2Engels
Pagina's (van-tot)228-237
Aantal pagina's10
TijdschriftClinical Immunology
Volume133
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - nov. 2009
Extern gepubliceerdJa

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