TY - JOUR
T1 - Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing
AU - Vermeij, Wilbert P
AU - Backendorf, Claude
PY - 2010/8/3
Y1 - 2010/8/3
N2 - Wound healing is a complex dynamic process characterised by a uniform flow of events in nearly all types of tissue damage, from a small skin scratch to myocardial infarction. Reactive oxygen species (ROS) are essential during the healing process at multiple stages, ranging from the initial signal that instigates the immune response, to the triggering of intracellular redox-dependent signalling pathways and the defence against invading bacteria. Excessive ROS in the wound milieu nevertheless impedes new tissue formation. Here we identify small proline-rich (SPRR) proteins as essential players in this latter process, as they directly link ROS detoxification with cell migration. A literature-based meta-analysis revealed their up-regulation in various forms of tissue injury, ranging from heart infarction and commensal-induced gut responses to nerve regeneration and burn injury. Apparently, SPRR proteins have a far more widespread role in wound healing and tissue remodelling than their established function in skin cornification. It is inferred that SPRR proteins provide injured tissue with an efficient, finely tuneable antioxidant barrier specifically adapted to the tissue involved and the damage inflicted. Their recognition as novel cell protective proteins combining ROS detoxification with cell migration will provide new venues to study and manage tissue repair and wound healing at a molecular level. © 2010 Vermeij, Backendorf.
AB - Wound healing is a complex dynamic process characterised by a uniform flow of events in nearly all types of tissue damage, from a small skin scratch to myocardial infarction. Reactive oxygen species (ROS) are essential during the healing process at multiple stages, ranging from the initial signal that instigates the immune response, to the triggering of intracellular redox-dependent signalling pathways and the defence against invading bacteria. Excessive ROS in the wound milieu nevertheless impedes new tissue formation. Here we identify small proline-rich (SPRR) proteins as essential players in this latter process, as they directly link ROS detoxification with cell migration. A literature-based meta-analysis revealed their up-regulation in various forms of tissue injury, ranging from heart infarction and commensal-induced gut responses to nerve regeneration and burn injury. Apparently, SPRR proteins have a far more widespread role in wound healing and tissue remodelling than their established function in skin cornification. It is inferred that SPRR proteins provide injured tissue with an efficient, finely tuneable antioxidant barrier specifically adapted to the tissue involved and the damage inflicted. Their recognition as novel cell protective proteins combining ROS detoxification with cell migration will provide new venues to study and manage tissue repair and wound healing at a molecular level. © 2010 Vermeij, Backendorf.
KW - Amino Acid Sequence
KW - Ascorbic Acid/pharmacology
KW - Cell Movement/drug effects
KW - Cornified Envelope Proline-Rich Proteins/chemistry
KW - Cysteine
KW - Gene Expression Regulation/drug effects
KW - HeLa Cells
KW - Humans
KW - Keratinocytes/drug effects
KW - Meta-Analysis as Topic
KW - Molecular Sequence Data
KW - Reactive Oxygen Species/metabolism
KW - Skin/drug effects
KW - Wound Healing/drug effects
UR - https://www.mendeley.com/catalogue/a3b0cd3b-cbf7-3697-ba3b-20f98c8bdaf9/
U2 - 10.1371/journal.pone.0011957
DO - 10.1371/journal.pone.0011957
M3 - Article
C2 - 20689819
SN - 1932-6203
VL - 5
SP - e11957
JO - PloS one
JF - PloS one
IS - 8
M1 - e11957
ER -