Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions

Jaap D. van Buul, Ilse Timmerman

Onderzoeksoutput: Bijdrage aan tijdschriftOpmerking/debat

45 Citaten (Scopus)


VE-cadherin-based cell-cell junctions form the major restrictive barrier of the endothelium to plasma proteins and blood cells. The function of VE-cadherin and the actin cytoskeleton are intimately linked. Vascular permeability factors and adherent leukocytes signal through small Rho GTPases to tightly regulate actin cytoskeletal rearrangements in order to open and re-assemble endothelial cell-cell junctions in a rapid and controlled manner. The Rho GTPases are activated by guanine nucleotide exchange factors (GEFs), conferring specificity and context-dependent control of cell-cell junctions. Although the molecular mechanisms that couple cadherins to actin filaments are beginning to be elucidated, specific stimulus-dependent regulation of the actin cytoskeleton at VE-cadherin-based junctions remains unexplained. Accumulating evidence has suggested that depending on the vascular permeability factor and on the subcellular localization of GEFs, cell-cell junction dynamics and organization are differentially regulated by one specific Rho GTPase. In this Commentary, we focus on new insights how the junctional actin cytoskeleton is specifically and locally regulated by Rho GTPases and GEFs in the endothelium.

Originele taal-2Engels
Pagina's (van-tot)21-31
Aantal pagina's11
TijdschriftSmall GTPases
Nummer van het tijdschrift1
StatusGepubliceerd - 2 jan. 2016
Extern gepubliceerdJa


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