Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

Keyphrases

• Aging 25%
• Amyloid Aggregates 25%
• Cell Fitness 100%
• Chaperone 100%
• Chaperone Network 25%
• Chronological Aging 25%
• Cortical Endoplasmic Reticulum 25%
• Cytoskeleton 25%
• Denaturation 25%
• Denatured Protein 25%
• Endoplasmic Reticulum 25%
• Energy-dependent 25%
• Insoluble Protein Deposit 25%
• Large-scale Structure 25%
• Live Cell Imaging 25%
• Misfolded Proteins 100%
• Misfolding 25%
• Neurodegeneration 25%
• Potentially Toxic Species 25%
• Protein Aggregation 25%
• Protein Misfolding 25%
• Protein Pathology 25%
• Proteotoxic Stress 25%
• Punctum 50%
• Q-body 100%
• Quality Control Strategy 25%
• Rapamycin 25%
• Sequestration 100%
• Stress Proteins 25%
• Stress-induced 25%

Biochemistry, Genetics and Molecular Biology

• Amyloid Protein 100%
• Cellular Imaging 100%
• Cytoskeleton 100%
• Denaturation 100%
• Denatured Protein 100%
• Heat Shock Protein 100%
• Protein Aggregation 100%
• Protein Misfolding 100%
• Quality Control 100%
• Volume 100%

Neuroscience

• Amyloid Protein 50%
• Chaperone 100%
• Cytoskeleton 50%
• Endoplasmic reticulum 100%
• Heat Shock Protein 50%
• Neurodegeneration 50%
• Protein Aggregation 50%
• Protein Misfolding 50%
• Sirolimus 50%