TY - JOUR
T1 - Spermatocytic seminoma
T2 - toward further understanding of pathogenesis
AU - Looijenga, Leendert Hj
N1 - Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
PY - 2011/8
Y1 - 2011/8
N2 - Human germ cell tumours comprise a heterogeneous group of neoplasms which, based on pathobiological, genetic and clinical characteristics, can be subdivided into different entities. One of these subgroups relates to the so-called spermatocytic seminomas, benign tumours only found in the testis, preferentially in elderly men. Various developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma. A recent study examining expression of spermatogonial markers shows that spermatocytic seminomas are a heterogeneous group of tumours, with a supposed difference in origin, ie the majority from A(pale) or B spermatogonia, and a minority from A(dark) spermatogonia. However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals.
AB - Human germ cell tumours comprise a heterogeneous group of neoplasms which, based on pathobiological, genetic and clinical characteristics, can be subdivided into different entities. One of these subgroups relates to the so-called spermatocytic seminomas, benign tumours only found in the testis, preferentially in elderly men. Various developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma. A recent study examining expression of spermatogonial markers shows that spermatocytic seminomas are a heterogeneous group of tumours, with a supposed difference in origin, ie the majority from A(pale) or B spermatogonia, and a minority from A(dark) spermatogonia. However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals.
KW - Antigens, Neoplasm/metabolism
KW - Biomarkers, Tumor/metabolism
KW - Gene Expression Profiling/methods
KW - Humans
KW - Male
KW - Neoplasm Proteins/metabolism
KW - Organic Cation Transport Proteins/metabolism
KW - Organic Cation Transporter 2
KW - Repressor Proteins/metabolism
KW - Seminoma/etiology
KW - Testicular Neoplasms/etiology
U2 - 10.1002/path.2939
DO - 10.1002/path.2939
M3 - Article
C2 - 21725972
SN - 0022-3417
VL - 224
SP - 431
EP - 433
JO - The Journal of pathology
JF - The Journal of pathology
IS - 4
ER -