Stem cells: Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

Hiroyuki Matsumura, Yasuaki Mohri, Nguyen Thanh Binh, Hironobu Morinaga, Makoto Fukuda, Mayumi Ito, Sotaro Kurata, Jan Hoeijmakers, Emi K. Nishimura

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

243 Citaten (Scopus)

Samenvatting

Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII collagen (COL17A1/BP180), a critical molecule for HFSC maintenance, to trigger HFSC aging, characterized by the loss of stemness signatures and by epidermal commitment. Aged HFSCs are cyclically eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle miniaturization. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in HFSCs, demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

Originele taal-2Engels
Artikelnummeraad4395
TijdschriftScience
Volume351
Nummer van het tijdschrift6273
DOI's
StatusGepubliceerd - 5 feb. 2016
Extern gepubliceerdJa

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