Strategies to target drugs to gliomas and CNS metastases of solid tumors

B. Milojkovic Kerklaan; O. van Tellingen; A. D.R. Huitema; J. H. Beijnen; W. Boogerd; J. H.M. Schellens; D. Brandsma

doi:10.1007/s00415-015-7919-9

Strategies to target drugs to gliomas and CNS metastases of solid tumors

B. Milojkovic Kerklaan, O. van Tellingen, A. D.R. Huitema, J. H. Beijnen, W. Boogerd, J. H.M. Schellens, D. Brandsma

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

17 Citaten (Scopus)

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The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

Originele taal-2	Engels
Pagina's (van-tot)	428-440
Aantal pagina's	13
Tijdschrift	Journal of Neurology
Volume	263
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1007/s00415-015-7919-9
Status	Gepubliceerd - 1 mrt. 2016
Extern gepubliceerd	Ja

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title = "Strategies to target drugs to gliomas and CNS metastases of solid tumors",

abstract = "The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.",

keywords = "Antibodies, Brain metastases, Glioma, Nanoparticles, Polymer-based nanocarriers, siRNA",

author = "{Milojkovic Kerklaan}, B. and {van Tellingen}, O. and Huitema, {A. D.R.} and Beijnen, {J. H.} and W. Boogerd and Schellens, {J. H.M.} and D. Brandsma",

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AU - Milojkovic Kerklaan, B.

AU - van Tellingen, O.

AU - Huitema, A. D.R.

AU - Beijnen, J. H.

AU - Boogerd, W.

AU - Schellens, J. H.M.

AU - Brandsma, D.

PY - 2016/3/1

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N2 - The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

AB - The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

KW - Antibodies

KW - Brain metastases

KW - Glioma

KW - Nanoparticles

KW - Polymer-based nanocarriers

KW - siRNA

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JO - Journal of Neurology

JF - Journal of Neurology

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Strategies to target drugs to gliomas and CNS metastases of solid tumors

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