Structural architecture and functional evolution of Wnts

Claudia Janda

doi:10.1016/j.devcel.2012.07.011

Structural architecture and functional evolution of Wnts

Claudia Janda

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

45 Citaten (Scopus)

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The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

Originele taal-2	Engels
Pagina's (van-tot)	227-232
Aantal pagina's	6
Tijdschrift	Dev Cell
Volume	23
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/j.devcel.2012.07.011
Status	Gepubliceerd - 14 aug. 2012
Extern gepubliceerd	Ja

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10.1016/j.devcel.2012.07.011

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title = "Structural architecture and functional evolution of Wnts",

abstract = "The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.",

author = "Claudia Janda",

note = "Funding Information: We thank the reviewers for constructive comments that greatly improved our manuscript. We acknowledge support from HHMI and NIH RO1-GM097015 to K.C.G. and from a Jane Coffin Childs Postdoctoral Fellowship to C.Y.J.; J.F.B. is a visiting scientist in the Garcia lab. ",

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Structural architecture and functional evolution of Wnts

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