Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

Keyphrases

• LRP6 100%
• FZD5 100%
• Catenin 100%
• Canonical Wnt Signaling 100%
• Cryogenic Electron Microscopy 100%
• Fiducial 100%
• Regenerative Medicine 50%
• Wnt Signaling 50%
• Agonism 50%
• Wnt3a 50%
• Stem Cell Biology 50%
• Morphogen 50%
• Surrogate Agonist 50%
• Canonical Wnt 50%
• Heterodimerization 50%
• G Protein-coupled Receptor 50%
• Wnt Signal Transduction 50%
• Single-particle cryo-EM 50%
• Chaperone 50%
• Complex Particles 50%
• Fiducial Markers 50%
• Structure-activity Relationship 50%
• Mechanistic Understanding 50%
• Allosteric Mechanism 50%

Biochemistry, Genetics and Molecular Biology

• Wnt Signaling Pathway 100%
• Cryo-Electron Microscopy 100%
• Catenin 66%
• LRP6 66%
• Stem Cell 33%
• Morphogen 33%
• Agonist 33%
• G Protein Coupled Receptor 33%
• Structure Activity Relation 33%
• Cross-Link 33%