TY - JOUR
T1 - Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology
AU - Sasaki, Nobuo
AU - Clevers, Hans
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/10
Y1 - 2018/10
N2 - Intra-tumor heterogeneity (genotypic and functional diversity among cancer cells within the same tumor) represents one of the key challenges in cancer medicine. As heterogeneity of cancer cells constitutes an important parameter in the development of therapy resistance, an accurate assessment of intra-tumor heterogeneity is essential for the prediction of drug resistance and development of effective treatment. In this review, we evaluate primary patient derived-tumor organoid technology as a new tool for colorectal cancer research and treatment. Furthermore, we discuss organoid use to understand intra-tumor heterogeneity, both in terms of mutational diversification and of diversification in drug sensitivity. Finally, we address the exciting recent results that show that tumor organoid technology is highly predictive for drug response in metastatic colorectal cancer.
AB - Intra-tumor heterogeneity (genotypic and functional diversity among cancer cells within the same tumor) represents one of the key challenges in cancer medicine. As heterogeneity of cancer cells constitutes an important parameter in the development of therapy resistance, an accurate assessment of intra-tumor heterogeneity is essential for the prediction of drug resistance and development of effective treatment. In this review, we evaluate primary patient derived-tumor organoid technology as a new tool for colorectal cancer research and treatment. Furthermore, we discuss organoid use to understand intra-tumor heterogeneity, both in terms of mutational diversification and of diversification in drug sensitivity. Finally, we address the exciting recent results that show that tumor organoid technology is highly predictive for drug response in metastatic colorectal cancer.
UR - http://www.scopus.com/inward/record.url?scp=85053798774&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2018.09.001
DO - 10.1016/j.gde.2018.09.001
M3 - Review article
C2 - 30261425
AN - SCOPUS:85053798774
SN - 0959-437X
VL - 52
SP - 117
EP - 122
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -