TY - JOUR
T1 - [18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation
AU - Queiró, Luisa
AU - Hulsker, Caroline C.C.
AU - Looijenga, Leendert H.J.
AU - de Krijger, Ronald R.
AU - Scheijde-Vermeulen, Marijn A.
AU - Kusters, Pascal J.H.
AU - Littooij, Annemieke S.
AU - van Leeuwen, Jeanette
AU - Braat, Arthur J.A.T.
AU - Mavinkurve-Groothuis, Annelies M.C.
N1 - Publisher Copyright:
© 2026 The Authors
PY - 2026/6
Y1 - 2026/6
N2 - Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.
AB - Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.
KW - Germ cell tumour
KW - Gliomatosis peritonei
KW - Immature teratoma
KW - Nodal gliomatosis
KW - [18 F]FDG-avidity
UR - https://www.scopus.com/pages/publications/105030481957
UR - https://www.mendeley.com/catalogue/419a8686-f58d-39e1-a0b9-c81aad1049aa/
U2 - 10.1016/j.ejcped.2026.100493
DO - 10.1016/j.ejcped.2026.100493
M3 - Article
AN - SCOPUS:105030481957
SN - 2772-610X
VL - 7
JO - EJC Paediatric Oncology
JF - EJC Paediatric Oncology
M1 - 100493
ER -