Survival analysis of 3 different age groups and prognostic factors among 402 patients with skeletal high-grade osteosarcoma. Real world data from a single tertiary sarcoma center

Richard E. Evenhuis, Ibtissam Acem, Anja J. Rueten-Budde, Diederik S.A. Karis, Marta Fiocco, Desiree M.J. Dorleijn, Frank M. Speetjens, Jakob Anninga, Hans Gelderblom, Michiel A.J. van de Sande

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

14 Citaten (Scopus)

Samenvatting

Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of survival in patients with high-grade osteosarcoma in different age groups and prognostic variables for survival and local control among the entire cohort. In this single center retrospective cohort study, 402 patients with skeletal high-grade osteosarcoma were diagnosed and treated with curative intent between 1978 and 2017 at the Leiden University Medical Center (LUMC). Prognostic factors for survival were analyzed using a Cox proportional hazard model. In this study poor overall survival (OS) and event-free survival (EFS) were associated with increasing age. Age groups, tumor size, poor histopathological response, distant metastasis (DM) at presentation and local recurrence (LR) were important independent prognostic factors influencing OS and EFS. Differences in outcome among different age groups can be partially explained by patient and treatment characteristics.

Originele taal-2Engels
Artikelnummer486
Pagina's (van-tot)1-13
Aantal pagina's13
TijdschriftCancers
Volume13
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 2021
Extern gepubliceerdJa

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