Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma

Keyphrases

• Activated B Cells 12%
• BCL6 25%
• Cell Identity 12%
• Cell of Origin 12%
• Combined Activity 12%
• Combined Targeting 12%
• Derepression 12%
• Diffuse Large B-cell Lymphoma (DLBCL) 100%
• Disruptor of Telomeric Silencing 1-like 100%
• Enhancer of Zeste Homolog 2 (EZH2) 100%
• Epigenetic Regulators 12%
• Epigenetic Writers 25%
• Germinal Center 100%
• Germinal Center B Cells 12%
• Identity Crisis 12%
• Malignant Behavior 12%
• Plasma Cell Differentiation 12%
• Polycomb Repressive Complex 2 (PRC2) 12%
• Poor Survival 12%
• Pro-proliferative 25%
• Single Treatment 12%
• Synergize 100%
• Transcription Factor 12%
• Treatment Modalities 12%
• Xenograft 12%

Medicine and Dentistry

• Antigen 12%
• B Cell 25%
• B-Cell Lymphoma 25%
• Cell Differentiation 12%
• Diffuse Large B-Cell Lymphoma 100%
• Enzymes 12%
• Germinal Center 100%
• Identity Crisis 12%
• Polycomb Repressive Complex 2 12%
• Transcription Factor EZH2 100%
• Transcription Factors 12%
• Treatment Modality 12%
• Upregulation 12%
• Xenograft 12%

Biochemistry, Genetics and Molecular Biology

• B Cell 100%
• Blood Plasma 8%
• Cell Differentiation 8%
• Cellular Differentiation 8%
• Derepression 8%
• Enzyme 8%
• Identity Crisis 8%
• Polycomb Repressive Complex 2 8%
• Transcription Factor EZH2 100%
• Transcription Factors 8%
• Upregulation 8%