Targeting germ cell tumors with the newly synthesized flavanone-derived compound mlo1302 efficiently reduces tumor cell viability and induces apoptosis and cell cycle arrest

Keyphrases

• Protein Expression 100%
• Germ Cell Tumor 100%
• Cell Cycle Arrest 100%
• Testicular Germ Cell Tumor 100%
• Induced Apoptosis 100%
• Tumor Cell Viability 100%
• Flavanones 100%
• Tumor Patients 66%
• Apoptosis 66%
• NCCIT 66%
• Clinical Benefit 33%
• Cell Viability 33%
• Tumor Cell Lines 33%
• Cisplatin-resistant Cells 33%
• Resistant Cell Lines 33%
• CDKN1A 33%
• Effective Treatment 33%
• Treatment Strategy 33%
• Cell Differentiation 33%
• Dysregulated 33%
• DNA Methyltransferase 1 (DNMT1) 33%
• Long-term Adverse Effects 33%
• DNA Methylation (DNAm) 33%
• Cytotoxic Effect 33%
• Target DNA 33%
• Cisplatin-based Chemotherapy 33%
• Caspase-8 33%
• Hypomethylating Agents 33%
• Partial Effects 33%
• Pluripotency Markers 33%
• Expression Array 33%
• BrdU Assay 33%
• DNA Methylome 33%
• Activated Caspases 33%
• NTERA-2 Cells 33%
• IC50 33%
• Synthetic Drugs 33%
• Cleaved Caspase 33%
• Profilers 33%
• Inhibitory Concentration 50 33%
• MIB1 33%
• Less Toxic 33%
• Flavonoid Compounds 33%
• DNA Methyltransferase Inhibitor 33%
• Decitabine 33%
• Synthetic Flavonoid 33%
• Caspase-2 33%
• Overtreatment 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Neoplasm 100%
• Cell Viability 100%
• Germ Cell Tumor 100%
• Flavanone 100%
• IC50 50%
• Chemotherapy 25%
• Cisplatin 25%
• Side Effect 25%
• Flavonoid 25%
• Expression Array 25%
• Decitabine 25%
• Caspase 8 25%
• DNA Methyltransferase Inhibitor 25%
• Broxuridine 25%
• DNA Methyltransferase 25%
• Drug 25%
• Caspase 2 25%
• Cytotoxicity 25%

Biochemistry, Genetics and Molecular Biology

• Flavonoid 33%
• Caspase 2 33%