Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: Role of intracellular tenofovir diphosphate levels and review of the literature

Milly E. Haverkort, Bas W. Van Der Spek, Paul Lips, Walentina A. Slieker, Rob Ter Heine, Alwin D. Huitema, Willem Bronsveld

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

20 Citaten (Scopus)

Samenvatting

We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia. Intracellular tenofovir diphosphate levels were measured in 1 patient and were found to be very high, with plasma tenofovir levels just slightly elevated. Fibroblast growth factor-23, a phosphaturic hormone, was decreased in both patients and is therefore unlikely to have a pathophysiological role in this pathology. The different potential factors contributing to the development of tenofovir-related kidney proximal tubular dysfunction are discussed and the data presented may help to further elucidate its pathogenesis.

Originele taal-2Engels
Pagina's (van-tot)821-826
Aantal pagina's6
TijdschriftScandinavian Journal of Infectious Diseases
Volume43
Nummer van het tijdschrift10
DOI's
StatusGepubliceerd - okt. 2011
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: Role of intracellular tenofovir diphosphate levels and review of the literature'. Samen vormen ze een unieke vingerafdruk.

Citeer dit