Samenvatting
We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia. Intracellular tenofovir diphosphate levels were measured in 1 patient and were found to be very high, with plasma tenofovir levels just slightly elevated. Fibroblast growth factor-23, a phosphaturic hormone, was decreased in both patients and is therefore unlikely to have a pathophysiological role in this pathology. The different potential factors contributing to the development of tenofovir-related kidney proximal tubular dysfunction are discussed and the data presented may help to further elucidate its pathogenesis.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 821-826 |
Aantal pagina's | 6 |
Tijdschrift | Scandinavian Journal of Infectious Diseases |
Volume | 43 |
Nummer van het tijdschrift | 10 |
DOI's | |
Status | Gepubliceerd - okt. 2011 |
Extern gepubliceerd | Ja |